英文摘要 |
To study the effect of raspberry on the body weight and lipid metabolism, thirty 5-week old SD male rats were assigned to one of the three groups after maintained on the chow diet for one week: control diet (C), control diet supplemented with 5% raspberry (R5), and control diet supplemented with 10% raspberry (R10). The body weight and diet intake were measured once a week and every other day, respectively. After keeping in the diets for six weeks, all animals were sacrificed to collect the blood, liver, and adipose tissues for further analysis. The results indicated that animals supplemented with raspberry started to show lower body weight compared with animals in regular group after maintaining in the diets for 4 weeks. The rats supplemented with raspberry also had lower liver and adipose tissue weight. Supplementation of raspberry decreased blood triglyceride level, but only 10% raspberry supplementation showed lowering effect on total cholesterol and low density lipoprotein-cholesterol (LDL-C). The animals in R5 and R10 groups had lower liver and adipose tissue weights compared with those in regular group. Western blot analysis indicated that supplementation of raspberry down-regulated the expression of acyl-CoA:eholesterol acyltransferase (ACAT) and microsomal triglyceride transfer protein (MTP), and up-regulated the expression of HMG-CoA reductase; however, the results had no statistical significance. |