抗牛心脂抗體與第六介白質在貝西氏病的研究

Study of Anticardiolipin Antibodies and Interleukin-6 in Behcet's Disease

吾人研究貝西氏病病人在疾病活性期及緩解期有關的體液因子。測量病人及健康對照組血中的抗牛心脂抗體，包括IgG、IgM及IgA亞型，以及溶解的第六介白質。抗牛心脂抗體IgG及IgM亞型在病人組有明顯的升高，於疾病緩解期則均下降。有高抗牛心脂抗體的病人則有明顯的神經系統表現。此外，病人組也有較高的血中第六介白質值，對刺激抗牛心脂抗體的產生則有幫助。總之，抗牛心脂抗體及第六介白質與貝西氏病人的系統性免疫反應有關。連續測定抗牛心脂抗體對評估疾病的活動性可能有所幫助。

The humoral factors involved in Behcet's disease were studied in patients during disease activity and after activity subsided. Anticardiolipin antibodies with IgG, IgM and IgA isotypes and soluble interleukin-6 were measured in serum samples from 15 patients and 15 healthy subjects. Elevated levels of IgG and IgM isotypes, not IgA isotype, anticardiolipin antibodies were found in the patient group, and levels dropped after disease activity subsided. The neurological involvement, not other manifestations, was found to be significantly associated with the raised aCL antibodies. In addition interleukin-6 levels were also elevated in the patient group, which may contribute to the production of anticardiolipin antibodies. In conclusion, anticardiolipin antibodies and interleukin-6 may be involved in systemic immune responses of patients with Behcet's disease. Serial measurements of anticardiolipin antibodies would be useful in evaluating disease activity.