纖維母細胞之生長及膠原合成的免疫調節作用

Immune Regulation of Fibroblast Growth and Collagen Synthesis

纖維母細胞的增生及膠原的過度合成，乃是某些以纖維化為特徵的慢性炎疾病之主要生物演變程序，如硬皮症、特異性肺纖維化、肝硬化及間質性腎炎等。最近的研究顯示單核細胞系統能調節纖維母細胞之生長及膠原的合成。在某些情況下，活化的淋巴球、單核球或巨噬細胞能分泌不同的可溶性因子，可以促進或抑制纖維母細胞之生長及膠原的合成。纖維母細胞亦可以分泌化學趨化物及干擾素，在和單核核細胞作用間扮演一個主動角色。因此隨著一個炎症刺激後，纖維母細胞和免疫細胞之間的相互作用乃是複雜的雙向而非單向的作用。

Fibroblast proliferation and/or collagen overproduction are the central biologic process in certain chronic inflammatory disease characterized by fibrosis, such as scleroderma, idiopathic pulmonary fibrosis, cirrhosis of the liver and interstitial nephritis. Recent investigation showed that fibroblast proliferation and collagen synthesis can be modulated by mononuclear cell system. Under certain condition, the lymphocyte- monocyte- macrophage were activated to secrete different soluble factors that stimulate or suppress the proliferation of fibroblast and collagen synthesis. Fibroblast also play an active role in the interaction between monuclear cell system by secreting chemoattractants and interferon. Thus, following an inflammatory stimulation, the immune response occurred between fibroblast and immune cells in a complicated, bidirectional rather than uni- directional way.