Study of Factors Affecting the Dissolution of Piroxicam Capsule

The result of in-vitro dissolution test of several experimental piroxicam capsule formulation is presented. It is shown that excipients have certain degree of effect on the dissolution of piroxicam capsule. The dissolution rate can be reduced, when the capsule contains magnesium stearate more than 5%; this may be due to the lamination and subsequent adhesion to the dry agglomerate. The mixing time of magnesium stearate didn't exhibit significantly effect on the test. It was also found that 0.75% and 1.56% of sodium Iaury) sulfate can increase the dissolution of piroxicam capsule which contains magnesium stearate. Heigher concentration of sodium Iaury) sulfate (3.12%) can decrease the dissolution. However sodium Iaury) sulfate is not recommended for the oral formulations and looking for the edible nonionic surfactant would be expected.