不同睡眠時數下進行八週高強度跑步訓練對B 型肝炎帶原者肝功能變化之研究

The effects of high intensity training in different sleep hours on hepatic parameters in hepatitis B carriers

目的：探討在不同睡眠時數下進行高強度運動訓練對健康B 型肝炎帶原者肝功能的影響。方法：本研究共募集16 位健康B 型肝炎帶原者為研究對象，其中包括8 位每日睡眠時間為6 小時（6H 組）及8 位每日睡眠時間為8 小時（8H 組），共兩組。兩組受試者皆須在跑步機上，從事運動強度為85%VO2max，時間為30 分鐘，每週3 次，共8 週的跑步運動訓練，並於實驗前 (T1)、第4 週訓練結束後 (T2)、第8 週訓練結束後 (T3) 及停止訓練4 週後 (T4) 進行抽血。所得肝功能資料均以混合設計二因子變異數分析加以檢定。結果：一、ALT 部分：6H 組的T2、T3 及T4 數值顯著高於T1 的數值 (p < .05)； 8H 組的T2 及T3 的數值顯著低於T1 的數值 (p< .05)。二、Globulin 部分：6H 組的T3 的數值顯著低於T4 的數值 (p < .05)；6H 組的T2 及T3 的數值顯著低於T1 及T4 的數值 (p < .05)。其他6 項指標則無顯著差異。結論：在足夠的睡眠時數下，高強度的運動訓練期間對於肝功能中ALT 及globulin 等肝功能指標是有益的；但在不足的睡眠時數下，高強度的運動訓練對於ALT 指標的部分是不利的，而且不良情形會持續出現到停止訓練後。

Purpose: The purpose of this study was to investigate the effects of high intensity training in different sleep hours on hepatic parameters in hepatit is B carriers. Methods: Sixteen male hepatitis B carriers were participated in this study. It includes eight subjects with 6 sleep hours (6H) and eight subjects with 8 sleep hours (8H). All subjects were be asked to run on treadmill at 85%V ‧ O2max, 30 minutes per day, three times a week for eight weeks. The blood samples collected at pre-training (T1), and post-4 weeks training (T2), and post-8 weeks training (T3), and 4 weeks after detraining (T4). All data will be analyzed by mixed design two-way ANOVA. Results:1) ALT: At 6H, the values at T2, T3 and T4 are higher than it at T1 (p < .05). At 8H, the values at T2 and T3 are lower than it at T1 (p < .05). 2) Globulin: At 6H, the value at T3 is lower than it at T4 (p < .05). At 8H, the values at T2 and T3 are lower than these at T1 and T4 (p < .05). Conclusion: In enough sleep hours, the good effects were shown during high intensity training time on ALT and globulin in hepatitis B carriers. Conversely, the adverse changes after 8 weeks training and 4 weeks after detraining were shown on ALT in poor sleep hours for hepatitis B carriers.