卵巢顆粒細胞瘤的治療

The Treatment Options for Granulosa Cell Tumor of the Ovary

卵巢顆粒細胞瘤是一種少見且發展緩慢的惡性腫瘤，病灶多為第I 期，預後良好，通常無需追加輔助治療。對手術後有復發的高危險因子、殘留病灶、無法切除的復發病灶，可使用化學治療，有需要時，可輔以放射線或荷爾蒙治療。對晚期或復發性病灶，亦可考慮使用荷爾蒙治療，或以bevacizumab做另一次替代治療法。患者需長期追蹤，因為有些GCT患者會在多年後才復發。

Granulosa cell tumors of the ovary (GCTs) constitute a rare subgroup carrying a malignant potential, since they have the ability to recur and metastasize. GCTs are generally associated with a favorable prognosis, and are diagnosed as stage I diseases. Therefore, many patients do not need adjuvant treatment after surgical treatment. Some regimen of combination chemotherapy is an option for patients with residual tumor or a high risk of recurrence. Hormone therapy or bevacizumab appears to be a good treatment alterative for patients with advanced-stage or recurrent GCT. A prolonged post-therapeutic follow-up is necessary because of the risk of recurrences, late and exceptional for the adult form.