大型輸注液內毒素汙染之測定

ENDOTOXIN CONTAMINATION OF LARGE VOLUME PARENTERALS AS DETERMINED BY LAL METHOD

本研究為探討大型輸注液內毒素污染的情形，於七十五年間在台灣地區普遍抽購大型輸注液549件，以LAL試驗法進行其細菌內毒素檢測，呈陽性者有9件，佔1.64%。其中國產製劑517件，呈陽性者有8件，佔1.55%；輸入製劑32件呈陽性者有1件，佔3.1%。此9 件LAL試驗呈陽性者經家兔熱原試驗檢驗結果均為陰性。

From July 1985 to June 1986, We examined 549 samples of large volume parenterals by the limulus amebocyte lysate (LAL) method. Of the total samples tested, 9 (1.64%) were found contaminating endotoxin. However, by using the official method for pyrogen test, none of the 9 endotoxin postive samples was able to induce typical fever response in rabbits.