利用氣相層析質譜儀同時分離及鑑別DIAZEPAM, NORDAZEPAM, FLUNITRAZEPAM. BROMAZEPAM, FLURAZEPAM HCI, ALPRA-ZOLAM及TRIAZOLAM等七種國內濫用藥物

SEPARATION AND IDENTIFICATION OF DIAZEPAM, NORDAZEPAM, FLUNITRAZEPAM, BROMAZEPAM, FLURAZEPAM HCI, ALPRAZOLAM AND TRIAZOLAM BYGC/MS

本報告是應用精確、快速的氣相層析質譜儀定性國內被濫用之精神神經安定劑、催眠鎮靜劑：Diazepam, Nordazepam, Flunitrazepam, Bromazepam, Flurazepam HCl, Alprazolam及Triazolam。目前國內甚多犯案使用之藥物多為上述成分，而對於Benzodia-zepine類催眠鎮靜劑之鑑別，一般使用薄層層析法及紫外光分光光度法做初篩試驗，但有時因雜質干擾或因各成分的化學結構類同，而無法得到鑑別結果，所以必需發展出一可同時分離及鑑別多種Benzodiazepine類催眠鎮靜成分之檢驗方法。利用氣相層析質譜儀以Electron-Impact Mode為電子源，層析管為2% OV-17，得到良好的分析效果，並可迅速提供準確的檢驗結果。

A rapid GC/EIMS procedure was developed for the separation and identification of diazepam, nordazepam, flunitrazepam, bromazepam, flurazepam HCl, alprazolam and triazolam. Codeine phosphate was used as the internal standard and OV-17 was chosen as an analytical column in this experiment. The seven benzodiazepines are commonly abused as criminal drugs in our society. This gas chromatographic analytical condition can give good resolutions and precise results rapidly.