固本解鬱法論治中風後抑鬱症（poststroke depression）對照研究

STUDY OF POSTSTROKE DEPRESSION TREATED BY THERAPY OF CONSTITUTION CONSOLIDATING AND DEPRESSION SMOOTHING

觀察臨床固本解鬱法與中風後抑鬱症（poststroke depression, PSD ）症狀改善的關係。162 例PSD 患者服用心脾解鬱湯治療為治療組，150 例採用阿米替林為對照組, 療程均為4 週。治療組對PSD 按密爾頓抑鬱量表（HAMD ）評價的總分及其中4 個因數等抑鬱狀態改善較對照組明顯，不良反應減少（P < 0.01 or P < 0.05 ）。PSD 發生的病理學基礎是腦出血或梗死　，心脾解鬱湯較傳統抗抑鬱藥對PSD 療效明顯，且無明顯不良反應。To investigale the relationship between the therapy constitution consolidating and depression smoothing (固本解鬱法 ) and the improvement of poststroke depression (PSD). 162 patients with PSD in treatment group took tonic to the heart and spleen & smooth depression decoction (心脾解 鬱湯 ), 150 patients with PSD in control group took amitriptyline. The treatment course was 4 weeks. After patients with PSD had been treated for 2,4 weeks, respectively, the total mark and the mark of each of our factors assessed by HAMD in treatment group were significatly lower than thosein control group (P < 0.01), The side effects of treatment group were less than those of control group (P < 0.05). The base pathogenesis of PSD is related to cerebral infarction or hemorrhage after apoplexy. The therapeutic effect of tonic to the heart and spleen & smooth depression decoction (心脾解鬱湯 ) on PSD is superior to that of traditional anti-depression drugs, without obvious side effects.