Background:Insulin injection is one of the most effective treatments for glu-cose control. However, insulin injections may lead to a decrease in quality of life for patients due to needle sticks during the injection process, and may even result in disease exacerbation if patients are reluctant to undergo injections. Purpose:Given the clinical observation and the collected feedback from unsatisfied insulin injection experiences, we presented a needle remover designed for removing needles from pen injections. It aims to alleviate the risk associated with needle loading/unloading and improve user satisfaction. Methods:We have developed a novel needle remover called “Bye2NeedleStick” using 3D printing technology. In addition, we admin-istered questionnaires related to clinical practicesto assess user satisfaction. Results:Given user feedback, the application of “Needle Care” can make it easier for users to inject insulin and lead to improved results to most of the survey questions. Conclusions: The " Bye2NeedleStick" needle remover for insulin pen injection can improve safety, usability, and reduce risks in clinical use. The product will continue to be improved addressing potential issues from the feedback of users.