Objective: Borderline personality disorder (BPD) is characterized by negative affect, including hostility, jitters, distress, guilt, and scared. The present study pro-posed that emotion sensitivity and emotional dysregulation predict negative affect in patients with BPD, and that emotional dysregulation mediates the relationship be-tween emotion sensitivity and negative affect. Method: Participants 31 BPD patients include 26 female and 5 male, with average age of 33.35 years old. All participants completed the Borderline Personality Inventory, the Emotion Evaluation Subtest, Positive and Negative Affect Schedule, and Difficulties in Emotion Regulation Scale. Results: Mediation analysis indicated that limited access to emotion regulation strategies mediated the relationship between anxiety sensitivity and overall negative affect, impulse control difficulties mediated the relationship between anxiety sensi-tivity and jitters, and non-acceptance of emotional responses mediated the relation-ship between aversion sensitivity and guilt. Conclusions: This has significant treat-ment implications, highlighting that learning skills in managing and regulating emo-tions, accepting one’s emotions, and avoiding self-destructive impulse behavior should be targets of intervention. Another implication of this finding is the im-portance of providing intervention to reduce emotion sensitivity in social interac-tions.