Higher nurse practitioner practice independence provides more effective solutions to modern health challenges such as health inequalities, aging society, and pandemic, etc. Nevertheless, consensus on nurse practitioners’ scope of practice is still underbuilding in Taiwan. While COVID-19 pandemic has drawn our attention towards cost-effective strategies to avoid system collapse, it is a great opportunity to redefine Taiwan nurse practitioner’s role in the pandemic and health care. Based on empirical evidence, the aim of this opinion paper is to critically describe what nurse practitioner independent practice is and how it can alleviate the burden on health system. We first presented the history and current status regarding nurse practitioners’ scope of practice in Taiwan and in other countries. Then we systematically discussed how governments in other countries temporarily expended or exempted the practice scope of nurse practitioner during the pandemic. We also commented on why nurse practitioners have the potential to solve healthcare resource shortages in difficult situations. Finally, we suggested to expend nurse practitioner’s role in Taiwan and hope to encourage relevant discussions and consensus building.