More than 60% of hemodialysis patients need surgical interventions for arteriovenous fistula stenosis or failure. Without adequate preventive treatments and follow-up actions, a high surgery rate resulting in increased medical costs is anticipated. The “ Clinical Care Guidelines of Non-Surgical Interven¬tions to Prevent Arteriovenous Fistula Failure” were developed through the following five phases. In phase one, a team was established for developing guidelines. In phase two, team members searched published literature before 2018 and identified seventeen related articles. In phase three, the level of evidence according to the 2015 Scottish Intercollegiate Guidelines Network (SIGN) was evaluated. The first draft of the clinical guidelines included 23 items (the scope of the guidelines remaining un¬defined). In phase four, expert validity of the draft was assessed by 10 clinical experts. In phase five, 46 clinicians and 10 hemodialysis patients were invited to evaluate the feasibility of the guidelines, and 21 items were selected for the final version of the guidelines. The clinical care guidelines consist¬ed of 5 constructs with a total of 25 items, including the scope of the guidelines (4 items), pharmaco¬logical treatments for arteriovenous fistula failure (3 items), nursing measures during hemodialysis (6 items), home care measures (4 items), and routine follow-up and management (8 items). With the development of the guidelines, we expect to lower the reconstruction rate of arteriovenous fistula and reduce medical costs through the prevention of arteriovenous fistula failure in hemodialysis patients
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