In clinical practice, right knee inflammation and pain is frequently considered to be caused by arthri-tis, gout, or cellulitis. In this case, a 49-year-old female patient who experienced recurrent right knee inflammation and pain was initially diagnosed with cellulitis. However, her right knee refractory pain and local skin damage showed conflicting results. A computed tomography scan and biopsy were performed and necrotizing fasciitis was revealed. Fasciotomy, repeated debridement and subsequent above-knee amputation were perfoemed. The infection was eventually controlled and she was then discharged. For patients with recurrent right knee inflammation and refractory pain, when the antibi-otic treatment is not effective and the clinical manifestation mismatches with pain score, necrotizing fasciitis must be considered as a possible differential diagnosis for punctual treatment.