Acromegaly is a complex and slow progressive disease which is caused by an elevated level of growth hormone and insulin-like growth factor-1. It may need to take 8 to 10 years to confirm the diagnosis.The major risk factors of acromegaly are pituitary tumor, central or peripheral tumors, and genetic diseases. Acromegaly carries a high mortality rate if it is not adequately treated. The clinical symptoms of acromegaly include changes in body appearance and systemic pathological changes, such as cardiovascular disease, glucose intolerance, respiratory and digestive diseases, and arthropathy.Transsphenoidal adenectomy is the priority therapeutic option for resection of pituitary tumor. Yet for patients who cannot have the tumor be completely removed or are intolerable to surgery, alternative treatments such as medication or radiation therapy are suggested. Nevertheless, some studies have shown that some medication for acromegaly may easily induce glucose intolerance or gastrointestinal upset. Moreover, the effectiveness of radiation therapy depends on the size and location of the tumor. Traditional radiation therapy often takes years to control this disease. Although stereotactic radiotherapy can accurately locate the lesion, has a short course for treatment, and can quickly improve the condition, still excessive radiation exposure to the chiasm should be avoided. Nursing care should focus on the pre- and post-surgery care of resection of pituitary tumor. Nurses are suggested to be familiar with the effect and side effects of medications, observation of complications, and how to relief the physical and psychological issues caused by the treatment procedures. Since the relevant literature in Taiwan is still lacking, we hope this article can help clinicians and nurses provide a better quality of management.