Anterior cervical spine surgery is a common procedure to treat cervical spondylosis. Its possible complications include wound infection, hematoma, dural tear, cerebrospinal fluid leakage, vocal cord paralysis, esophageal perforation, and dysphagia; therefore, careful evaluation and monitoring are necessary. This patient was a 57-year-old male who underwent anterior cervical spine surgery due to cervical spondylosis. After the operation, he had no obvious wound infection but complained of choking and difficulty swallowing his liquid diet. He was discharged after achieving symptomatic relief via the use of steroids. However, he experienced sore throat, local heat, and dysphagia a few hours later and returned to our emergency room for further evaluation. Additional imaging studies revealed esophageal perforation with deep neck infection. He then underwent esophageal repair and debridement.Leakage was found at the repair site on the eighth postoperative day, and rotational muscle flap coverage was performed. After these treatments and with adequate drainage and nutritional support, his condition gradually improved, and he was discharged 41 days after rehospitalization. Esophageal perforation is a rare and possibly fatal complication which can occur after anterior cervical spine surgery. Esophageal perforation should be particularly suspected, even when the patient presents common symptoms such as dysphagia, hoarseness, pneumonia, fever, or dyspnea, any of which may occur after anterior cervical spine surgery. The only way to minimize the consequences of this potentially serious complication is through early detection and timely treatment.