Unplanned extubation (UPE) events cause a serious hazard to patient safety and are reflective of patient care quality issue. The aim of this project was to reduce the UPE rate in the NICU. Factors leading to UPE included head rolling when agitated, adhesive tape loosened by copious secretions, malpositioning by healthcare provider, unsupported ventilation tubing, and incomprehensive care. The implemented interventions were as follows: (1) provided continuing education courses regarding endotracheal tube care; (2) revised the policy for “standard care for endotrachea tube” with new pictorial description, modified prone sleep positioning, endotracheal tube stabilization by using water resistant tape, and ventilator circuit fixation; (3) developed a team reward system; and (4) developed a quality monitoring program after implementation of above interventions. After implementation of this program, the UPE rate decreased from 0.65% to 0.19% and rate of appropriate endotracheal care was increased from 67% to 94.3%, which met our goal. Through this project, health care workers are able to provide better quality of care and prevent inadvertent extubation.