Bezoar is an uncommon clinical gastrointestinal problem, which is mostly caused by indigestible food debris that overstays in the gastrointestinal system. When the gastrointestinal tract is obstructed by bezoars, the patient will experience nausea, vomiting and abdominal distension. We reported a 62-year-old man with diabetes mellitus presenting to emergency room with lower abdomen dull pain for two days and accompanied by nausea and vomiting. He was diagnosed as small bowel ileus with bezoars impaction from series image studies. The bezoars were smoothly passed out after Coke and prokinetic agents were given. When bezoar is blocking the small intestine, it can not be retrieved by therapeutic endoscopy. Surgical intervention is recommended, and it certainly requires a longer recovery period of postoperative care especially in the patient with diabetes. The initial treatment plan is to maintain internal medical supportive therapy, such as: fasting, a lot of fluids, soft stools and prokinetic drugs. Additional daily use of low-calorie Coke 600cc supportive therapy was also applied. The patient was treated with 600cc of Coca-Cola per day and supportive care. After two days of the treatment he restored bowel movement and abdominal pain was significantly relieved. As well, the following up small bowel series confirmed disappearance of bezoars. The experience of this patient could be provided as a reference for clinical application.