This case report shares the experience of taking care of a 52 year-old male diagnosed with small cell lung cancer and metastasis of chest wall and aorta in a surgical ward from September 26, 2011 to December 12, 2011. Due to the rapid growth of the chest wall tumor and quick progression of the disease, the treatment course was changed from aggressive surgical intervention to palliative and hospice care. Data were collected through active listening, interview and physical examination. Results of the physiological, psychological, social and spiritual assessment showed that the patient had problems on “malignant wound of terminal cancer”, “conflict with the medical team in therapeutic goals due to patient’s insisting on self-directed care”, and “knowledge of terminal cancer”. Being a nurse practitioner, the author helped the patient and his female partner faced the anticipated grief associated with terminal cancer, and established a more positive attitude toward death. During the care process, the roles of a nurse practitioner in direct care giver, educator, consultant, researcher and coordinator were emphasized and various resources from the multidisciplinary medical team were integrated to help the patient and his close relatives completing the final stage of the patient’s life without regret.