中藥質量控制指標成份選擇之困難和誤區   全文下載

Pitfalls of the Selection of Chemical Markers for the Quality Control of Medicinal Herbs

指標成份的選擇對中藥質量控制和標準化至關重要。理想的指標成份是與中藥治療功效相關聯的成份。但對大多數常用中藥來說，有些所含有的化學成份的生物活性不明確，有些所含有的成份含量變化較大，其存在與否難以預測和控制，這類成份不是理想的指標成份。因此本文將指標成份分為七種類型，並以中藥川芎指標成份的研究為例，探討中藥質量控制過程中選擇指標成份時遇到的困難和可能存在的誤區。

Selection of chemical marker is critical to the quality control and standardization of medicinal herbs. The ideal chemical marker is the active principle with demonstrated clinical efficacy contributing to the therapeutic effect of the herb, while the worst ones are the analytical marker and “phantom” marker whose pharmacological actions are unknown, uncontrollable or unpredictable. In this article, we explore the seven categories of chemical markers, discuss the pitfalls of choosing them, and illustrate the problems using a traditional Chinese medicinal herb Ligusticum chuanxiong as an example.