中藥標準提取物：丹參標準提取物研究   全文下載

Standardized Extracts of Chinese Medicinal Herbs: Case Study of Danshen (Salvia miltiorrhiza Bunge)

全球興起的食用天然藥物或天然產物營養補充劑調理健康的熱潮，引起了人們對草藥產業發展的廣泛關注。然而，草藥製劑的藥理功效不是由單一組分產生，而是複雜成分混合物協同作用的結果，這與化學合成藥物是不同的。這就急需發展草藥標準提取物作為標準參考物質，用於新藥篩選、製劑生產以及品質評價。這篇綜述的重點在於討論製備標準提取物的過程，以及用於控制標準提取物各項生化指標的現代分析技術。目前筆者所在的實驗室正展開標準提取物的研究工作，在這篇文章當中，將以這項研究中所涉及的一些關鍵技術為例進行討論，尤其著重以中藥材丹參為例說明提取物製備以及標準化的全過程。

The global trend of favoring healthcare with medicines or neutraceuticals derived from natural products has prompted an increasing interest recently on the development of herbal medicines. However, unlike synthetic chemical drugs, the pharmaceutical actions of herbal products often cannot be attributed to a particular compound, but owe rather to the synergy of a complex compound mixture. This calls for the urgent need to develop standardized extract to serve as reference materials for researches involved in drug discovery, product development and quality assessment. The emphasis of this review is to discuss the processes employed to prepare the extracts, and the techniques used to standardize their biochemical properties. Real cases, in particular those carried out in the author’s own laboratory, will be used to exemplify major technical issues involved in these studies. Danshen (Salvia miltiorrhiza Bunge) in particular, will be used as a case study to illustrate the processes involved in extract preparation and standardization.