肉蓰蓉(Cistanche deserticola)對於大鼠自發運動量之影響

Effects of Cistanche Deserticola on Spontaneous Motor Activity in Rats

本研究使用運動量測定儀探討肉蓰蓉(Cistanche deserticola)（簡稱CD）對於大鼠自發運動量之影響。結果顯示肉蓰蓉粗抽物可減低大鼠自發運動量，包括水平運動、走動時間及移動總距離。肉蓰蓉各層分離物中以水層分離物減弱自發運動量的作用最強。肉蓰蓉水層分離物可增強。α-MT，muscimol所誘發的水平運動、走動時間及移動總距離減少，並減少apomorphune所誘發的水平運動、走動時間及移動總距離增加。肉蓰蓉水層分離物可增強5-HTP誘發之水平運動、走動時間減少，並減少pchlorophenylalanine所誘發的水平運動、走動時間增加；但對於5-HTP誘發之移動總距離減少及PCPA誘發之移動總距離增加均無影響。肉蓰蓉水層分離物對於baclofen所誘發之運動量降低亦無影響。這些結果顯示，肉蓰蓉水層分離物所產生的運動量降低可能是由於減弱dopaminergic系統活性及增加serotonergic及GABAergic系統活性所致。肉蓰蓉水層分離物所產生的移動總距離減少與serotonergic系統無關。

In this study, we investigated the effects of Cistanche deserticola Ma. (abbreviated as CD) on spontaneous motor activity by using an automated activity meter in rats. It was found that crude extract of CD reduced horizontal activity. The water fraction of CD extract (Fr Ⅲ) reduced the horizontal activity more than other fractions of CD extract in rats. Fr Ⅲ enhanced the decrease in the horizontal activity produced by α-methyl-p-tyrosine, 5-hydroxytryptophan and muscimol, reduced the increase in the horizontal activity produced by l-dopa plus benserazide. p-chlorophcnylalanine, and bicuculline. Furthermore Fr Ⅲ did not augment the hypomotility produced by baclofen. These results suggest that the hypomotility produced by Fr Ⅲ may be due to the decrease in the dopaminergic activity and the increase in the serotoncreic and GABA(subscript A) crgic activities.