補充純氧對吸菸者肺功能、體能及血液生化值之影響

Effect of pure oxygen on the pulmonary function, physical fitness and blood biochemistry value of the smokers

目的：探討補充純氧對吸菸者肺功能、體能及血液生化值的影響。方法：以30位自願接受實驗之男性為對象，隨機分配至實驗組15人（年齡20.40±1.00歲、身高173.67±4.12㎝、體重70.87±6.98㎏、菸齡1.77±0.67年，一天菸量10.80±4.00支），控制組15人（年齡20.20±0.80歲、身高173.73±4.59㎝、體重67.70±7.14㎏、菸齡1.74±0.58年，一天菸量10.77±3.89支）。實驗前先進行前測，測驗項目有肺功能檢查：以肺量計spirometer測定用力肺活量（FVC）、第一秒鐘吐氣量（FEV1.0）、第一秒鐘最大吐氣量率（FEV1.0／FVC）及呼氣流量尖峰（PEFR）；體能測驗：以坐姿體前彎、一分鐘屈膝仰臥起坐與3000公尺跑走；脂質過氧化：以HPLC測定TBA-MDAadduct及血液生化檢查：以自動化血液生化分析儀及血球計數器分別測定三酸甘油脂（TG）、總膽固醇（cholesterol）、葡萄糖（glucose）與全套血球計數（complete blood count）等。實驗期間受試者每天吸取純氧30分鐘，連續30天後進行後測，所得數據以SPSS for windows 10.0統計軟體處理，並以共變數分析（ANCOVA）進行考驗。結果：實驗組與控制組在身體型態上並無顯著差異（p>.05），實驗組在肺功能檢查中，第一秒鐘最大吐氣量率（FEV1.0／FVC）、呼氣流量尖峰（PEFR）及體能測驗3000公尺跑走有顯著差異（p<.05）。脂質過氧化物（MDA）與血液生化檢查兩組間並無顯著差異（p>.05）。結論：補充純氧的確對吸菸者在肺功能及運動測試上有所幫助。

Purpose: The study was to evaluate the pulmonary function, physical fitness and blood biochemistry value of smokers before and after pure oxygen exposure. Method: Thirty males volunteer were randomized to test group (15 males with a mean age 20.40±1.00years, height 173.67±4.12㎝, weight 70.87±6.98㎏, smoking experience 1.77±0.67 years, diary cigarette 10.80±4.00), and control group (15males with a mean age 20.20±0.80 years, height 173.73±4.59㎝, weight 67.70±7.14㎏, smoking experience 1.74±0.58 years, diary cigarette 10.77±3.89). The test items included pulmonary function: FVC, FEV1.0, FEV1.0/ FVC, and PEFR; physical fitness: sit and reach, one minute sit-up and 3000 meters run-walk; blood biochemistry value: MDA, TG, cholesterol, glucose and CBC (complete blood count). After the pretest, the participants inhaled 100% oxygen for 30 minutes per day. Ongoing one month oxygen exposure duration, the posttest was took place. All the data were processed by SPSS for Windows 10.0 statistic software and ANCOVA. Result: No differences were found in age, height, and weight (p>.05) between two groups. Significant differences were found in FEV1.0/FVC, PEFR and 3000 meters run-walk between test and control group (p<.05). The data had shown no differences between two groups in CBC and biochemistry value. Conclusion: The pulmonary function and physical ability were improved in smokers after pure oxygen exposure. We concluded that oxygen exposure has the beneficial effect of smokers' physical fitness and pulmonary function.