Clinical practicum has been one of the major sources of stress for students. The aim of this crosssection survey was to explore the sources of stress and their influencing factors on respiratory care students during clinical practicum. A total of 58 subjects were a convenience sampling of respiratory students and a structured questionnaire was used for data collection during the clinical practicum in 2014. The questionnaire was composed of two parts: the basic information and a Stress Scale. Data was analyzed by using SPSS 20.0 for Windows software. The results showed that students perceived a mild level of stress (2.22 ± 0.64). The major stressor was Homework/workload (2.45 ± 0.67), followed by worrying about insufficient professional knowledge and skills (2.42 ± 0.86), and practice environment (2.26 ± 0.73). The results are hoped to give some useful information for clinical teachers to provide assistance and counseling to students of respiratory care and maximize their efficacy of clinical practice.