In recent years, Taiwan has seen a frequent occurrence of major industrial accidents. Statistics from the Ministry of Labor’s Occupational Safety and Health Administration (OSHA) indicate that over the past few years, an average of more than 300 people have died annually due to severe occupational disasters. The construction industry has the highest incidence rate, followed by the manufacturing sector. The primary causes of these accidents are falls, rolling objects, electrocution, and collapsing structures, reflecting inadequate safety management and corporate social responsibility (S) within businesses. These frequent and severe industrial accidents not only pose a significant threat to the lives and health of workers but also damage corporate reputation and market valuation. However, previous literature has largely focused on analyzing single industries and short-term market reactions. There is a scarcity of research that examines the impact of major industrial accidents on corporate stock prices from a cross-industry perspective, specifically integrating an ESG viewpoint. Therefore, this study employs the event study methodology to investigate the abnormal returns and cumulative abnormal returns of Taiwanese listed companies after a major industrial accident. Furthermore, mean difference tests are used to compare whether significant differences exist in stock price fluctuations across various industries. The empirical results demonstrate that major industrial accidents negatively impact corporate stock prices, with variations observed across different observation periods and industry characteristics.