Remote work offers various advantages of efficiency and productivity for employees, especially IT professionals, business travelers, and freelancers. However, some drawbacks of remote work, such as distractions, isolation, and technology dependence, could elicit stress and burnout - which have negative effects on employees’ well-being. This research aims to gather factors affecting remote work burnout by differentiating stress into technostress - stemming from the use of technology, and work stressors - related to work overload and work-life conflict by employing the Technology - Organization - Environment (TOE) framework and Technostress. A survey instrument was used to gather data from 446 valid responses and examine the research model. Data was analyzed based on Partial Least Squares (PLS). The findings reveal the significantly positive impacts of technostress and work stressors on remote work burnout. Additionally, technology complexity and security requirements have important impacts on technostress, whereas home environment characteristics, including distractions and social isolation exacerbate work stressors. This research can be a reference for policymakers to place greater emphasis on corporate social responsibility in the remote work setting.