This article integrates clinical nursing practice, experiences of accompanying transgender individuals, and real-world healthcare cases to examine issues of healthcare quality and patient safety faced by transgender people within the medical system. Observations indicate that even after completing legal sex marker changes on national identification documents, transgender individuals may continue to face risks of involuntary disclosure during healthcare encounters due to misalignment among legal gender,physical anatomy, and specialty-based clinical classifications. Such involuntary disclosure is not an isolated or incidental phenomenon; rather, it constitutes a structural risk that adversely affects patient safety and healthcare quality, potentially interfering with clinical decision-making, patient–provider communication, and overall quality of care. This article compares Taiwan’s current legal gender change requirements with international trends toward non-surgical legal gender recognition, and, through both local and international healthcare experiences, illustrates the critical role of frontline healthcare professionals’ gender sensitivity, communication practices, and clinical responses in enhancing patient safety and trust in healthcare settings. Finally, this paper proposes transgender-inclusive care strategies centered on organ based clinical assessment, respect for self-identified gender, and the establishment of supportive environments for safe disclosure, aiming to provide practical guidance for healthcare institutions seeking to advance gender-inclusive practices and healthcare quality improvement.