As emerging Arctic sea routes and the region’s vast reserves of strategic resources—such as oil and natural gas—come to the forefront, significant transformations are unfolding in the global supply chain and international security landscape. Grounded in the theoretical framework of structural realism and employing qualitative research methods, this study investigates the strategic interactions among the United States, China, and Russia in the Arctic and Indo-Pacific regions amid intensifying geopolitical and military competition. The research demonstrates that the military, economic, and diplomatic alliance arrangements among these great powers form the causal basis of their strategic interactions. The findings suggest that if Arctic maritime routes were to supplant Indo-Pacific sea lanes, a shift in the strategic positioning between the United States and China would ensue; furthermore, the ongoing great power rivalry is evolving into a dual-front strategic configuration, positioning the Arctic as a pivotal strategic high ground with profound implications for reshaping the future global security order.