This article presents the author’s clinical observations in the intensive care unit (ICU), with these later enriched by formal ICU training, which led to a deeper understanding of delirium and its clinical implications. It contrasts the approaches of two night-shift nurses in managing light and noise, reflecting on how subtle differences in care may influence patient outcomes, including the high incidence of posttraumatic stress disorder among ICU survivors. The PADIS (pain, agitation, delirium, immobility, sleep disruption) Guideline introduced in training emphasizes the importance of nonpharmacologic interventions for delirium prevention, such as early mobilization, circadian rhythm reestablishment, and sensory reorientation. The author further highlights that preventing delirium is not an additional burden but a return to the essence of humancentered care. This insight inspires a call for caregivers to recognize the profound effects of their daily practices on a patient’s mental state and long-term recovery. Simple but intentional actions can not only sustain life but also preserve the patient’s sense of self.