The “uses and gratifications” theory emphasizes audience initiative and activeness for the use of media, which has been widely cited. This study collected 120 articles published in English periodicals from 1981 to 2020 for a content analysis to explore two questions: “factors for using media”, and “media and users investigated”. The findings for question 1 show that several factors, including a main factor and 7 sub-factors among different main factors reached statistically significant differences between articles published between 1981-1996 and 1997-2020. The results for question 2 show that the types of media and the generations of users in sample articles also reached statistically significant differences. Overall, for the new generations, such as Generation Y and Z, the media attributes of operation, expressiveness, and connection matter the most. The unchanged factors for using media across generations are obtaining information, entertainment, and interaction. Finally, this study provides suggestions about the data, methods, etc. for further research.