This study starts with the concept of "application, namely ranking and planning". After separating by building type, group the types into “Priority Group”, “Sub-Prime Group”, and “Alternative Group” according to the current COVID-19 situation, and plan the required application review items based on the features of each group. It is recommended that quarantine hotels prioritize independent buildings and then lower-floor hotels. For multi-purpose medium-high floor, other floors are better for simple purposes, and common fire escape management must be implemented. Multi-purpose medium-high floor (vacant) are the least recommended type. In addition, due to the complex fire protection and evacuation features of quarantine hotels, it is important to consider whether the conditions for equipment and fire rescue are met. Finally, start with the three core concepts of "application, namely ranking and planning", "maintenance, management, and self-assessment are needed during use", and "inspection, with professional checking and auditing", to research and plan the "Reference Guideline for Fire Evacuation Safety of Quarantine Hotels".