In this article, we discussed and compared the religious coping strategies of Taiwanese and Turkish parents of children with cancer, living in two different cultures, in order to draw attention to the importance of the religious/spiritual dimension of human experience. Cancer is one of the leading causes of disease-related death and treatment-associated morbidity in children with an increasing trend in recent decades worldwide. Religious coping is an effort to understand and deal with life stress in ways related to the sacred, which includes prayer, congregational support, pastoral care, and religious faith. Religious coping has been frequently used by Taiwanese and Turkish parents of children with cancer because it brings psychospiritual benefits; however, the religious coping strategies used are largely different since the parents’ religious beliefs and practices are different. While the beliefs of most Taiwanese parents are traditional folk beliefs and Taoism, the belief of most Turkish parents is Islam. We strongly believe that healthcare professionals should recognize and respect parents’ religious and spiritual needs and encourage parents to use religious coping strategies.