This project was conducted to reduce permanent vascular access obstruction in patients undergoing hemodialysis. The average rate of permanent vascular access obstruction in our unit from April to June 2019 was 5.37%, which is 3% higher than the quality monitoring index. An analysis of possible causes revealed that repeated injections at one location, the failure of primary care providers to perform home vascular access care, a lack of standardization for locating puncture sites, and a lack of group education are highly associated with high blockage rates. Through team collaboration, the rope ladder technique and audit system were incorporated. Home vascular access care charts and checklists were also provided. In addition, health passports and quick-response codes for chronic kidney disease were provided. Moreover, group health education programs and posters were organized. After project management, the permanent vascular blockage rate decreased from 5.37% to 1.07%. We not only improved the vascular care capacity but also strengthened the relationships between departments. Overall, the rates of vascular blockage decreased.