In the article, we summarized our endeavor in reaching an in-depth understanding of the struggle between illness and self-identity and other related mental health issues of an adult chronic patient in an internal medicine ward through clinical interviews, an endeavor prompting us to recognize the crucial importance of empathy in treating adult chronic patients struggling with changing perceptions of self-identify and illness representation. The patient in this case was a 31-year-old male who reported to his visiting staff that family conflicts had caused his depression and suicidal ideation. During the clinical interview, the patient expressed that he often fell victim to self-doubt because of being trapped in the hospital or hearing others criticize him, and he longed for death to find relief. Patients with chronic diseases often need to compromise their lives due to the illness and may struggle between resisting and accepting the illness, which can have adverse impacts on their mental health and disease control. The author suggests that medical practitioners should foster and use their empathy to help patients adjust their perceptions of self-identity and illness representation, encouraging patients to better cope with the impacts of their chronic diseases.