The COVID-19 outbreak since 2020 has affected the palliative care services in several countries. With the threat of the COVID-19 pandemic reaching its peak in May 2021 in Taiwan, members of home-based palliative care teams were facing an enhanced risk of contracting COVID-19 during home visits. This article focused on examining how a regional hospital practiced and modified related epidemic prevention measures on a rolling-basis to continue its home-based palliative care services with quality health monitoring and management. Proper training, pre-visit risk assessment, prevention measures and equipment during visit, and post-visit equipment sterilization were implemented in compliance with strict protocols to protect the safety of frontline health workers. When appropriate, audio-video transmission and other technologies were used to expedite timely medical communication and to provide patients and their families with professional guidance concerning hospice care at home. By sharing these experiences, we hope to offer insights beneficial in practicing effective prevention measures for frontline providers of home-based palliative care during an epidemic.