This article describes a 16-year-old child with end-stage renal disease who started hemodialysis in 2010. The severe and complicated disease led to frequent admissions and discharges, which seriously affected the quality of life. End-stage renal diseases requiring chronic dialysis are rare in childhood and adolescence. However, medical staff with lack of relevant care experience, have difficulty to assess symptoms and implement nursing measures. The duration of nursing care, from June 20 to September 20, 2020, through chatting, games and other methods to establish a good therapeutic relationship with the child and their family members. The author was through direct care, observation, revisited to identify the patient’s resilience in the dimensions of physiology, mental status, society, and spirituality. It is confirmed that there are three health problems: (1) resilience disorder, (2) comfort disorder, and (3) nutritional imbalance. Therefore, in the process of building trust in the nursing relationship and use the concept of resilience to provide individual caring schemes of patient and their families, reduce risk factors and improve protective factors, increase positive healthy behaviors to improve quality of life and adapt to diseases. The author also initiates cross-team care to improve the patient nutritional imbalances, relieve itching and pain symptoms with comfort care. It is recommended that use care and resilience to provide individual caring schemes based on the perspective and strengthen the recognition, self-caring techniques, and family supportive systems of patients, increasing patient perceptions of self-worth, restoring their confidence, promoting their adaption to their disease, and improving life of quality.