COVID-19大流行影響了整個世界的醫療、生活及經濟，世界衛生組織(WHO)宣稱COVID-19疫苗，將是結束這場瘟疫必須也是最有效的工具。文獻指出，COVID-19群體免疫的閾值可能介於疫苗接種涵蓋率55%至82%之間。臺中榮民總醫院積極配合國家政策，以滾動式修正，機動性調整疫苗接種作業，提供短時間內有效率的大量疫苗接種。執行大規模COVID-19疫苗接種歷需要五項策略。策略一、『事前規劃，當責領導』，首重集權式當責領導，能夠有效發揮跨部門整合包含醫師、藥師、護理師、資訊、工程、總務、醫企與教材組等，予以團隊清楚指令，並能及時監控成效。策略二、『人力盤點，團隊成軍』，大規模疫苗注射計劃需要深思熟慮和反覆規劃，透明和及時溝通，疫苗接種現場人員相互支持，協調合作和充分賦權。策略三、『空間場勘，最適規劃』，空間場勘選定場所，將有限空間做最大的運用與最適規劃。策略四、『流程規劃，以人為本』，接種流程規劃，是以「人」為考量，包括了工作人員與接種民眾的需求為出發點，以提供盡可能的友善措施與特別需求的個別協助。策略五、『巧推運用，省時省力』，巧妙運用非理性層面的驅力(drives)使民眾不自覺產生期待行為，進而使整個疫苗接種流程更加順暢。預防接種一直以來是為預防保健與中止傳染病的重要手段，以往傳統的大量流感疫苗接種方式，面對新冠疫苗大規模接種的挑戰時已不敷應付。規劃大規模疫苗接種計畫的經驗，一同反思舊有的模式，調整作法與分享經驗，以應對未來更多未知的醫療保健服務挑戰。

The World Health Organization (WHO) has declared that the COVID-19 vaccine will be the necessary and most effective tool to end the COVID-19 pandemic, which has affected the health, livelihood and economy of the entire world. The literature suggests that the threshold for COVID-19 herd immunity may range from 55% to 82% of vaccination coverage. In active compliance with the national policy, Taichung Veterans General Hospital has adjusted its vaccination operation on a rolling basis to provide a large number of efficient vaccinations within a short period of time. Five strategies are needed to implement a massive COVID-19 vaccination program. Strategy 1: “Advance planning and responsible leadership,” Strategy 2: “Manpower inventory and team building,” Strategy 3: “Space and site survey for optimal planning,” Strategy 4: “People-oriented process planning,” and Strategy 5: “Use of nudge theory to save time and effort.” Vaccination has long been an important tool for preventive health care and the prevention of infectious diseases, but it is clear that the traditional mass influenza vaccination approach is no longer sufficient to meet the challenges of mass vaccination with the new vaccine. The experience of planning a mass vaccination program has allowed us to reflect on the old model, adjust our practices, and share our experiences to meet more unknown challenges in health care delivery in the future.