In the scenario of node failure in mobile multi-agent, Ad hoc On-demand Distance Vector (AODV) rout-ing protocol fails in network information transmission due to the damage of communication link. In addi-tion, the existing AODV multipath routing protocol node load balancing mechanism is imperfect. In order to solve the low network survivability caused by the above problems, an improved responsive multipath routing protocol MD_AODV (Multipath Destroy-resistance AODV) is proposed. The protocol is opti-mized in three aspects: multi-channel concurrency mechanism, node load balancing mechanism and shortest path maintenance mechanism. The simulation analysis of the modified AODV multipath routing protocol is realized on OPNENT simulation platform. The simulation results show that compared with AODV protocol, the improved multipath routing protocol can enhance the utilization of network re-sources and has better link redundancy. Moreover, the modified routing protocol not only enhances the reliability and fault tolerance of the path, but also increases the network aggregation bandwidth.