This study describes the experience of providing nursing care to a hemodialysis patient who experienced acute rejection following a kidney transplant. The period of care lasted from January 6, 2020 to January 21, 2020. Data was collected through conversations, listening sessions, observations, physical assessments, and medical record reviews. The patient was found to be suffering from health problems such as acute pain, a potential risk of infection, and anxiety. Watson’s theory of human caring was applied to establish a strong nurse-patient relationship and to provide personalized nursing care. The patient’s acute postoperative pain was managed and controlled by means of pain alleviation methods such as respiratory control and medication treatment-based interventions. The patient’s potential risk of infection was managed by focusing on the implementation of wound care as well as infection prevention measures at the patient’s home after discharge. Furthermore, since the patient’s albumin level was lower than normal following a double filtration plasmapheresis, a multidisciplinary team was formed, and the patient consulted with a dietician who provided nutritional recommendations such as having a high protein diet. When the patient expressed uncertainty about the future or felt anxious about unfamiliar treatments, the team not only thoroughly described the treatments beforehand, but also enhanced the mental and spiritual support that they provided by expressing concern about, listening to, and placing faith in the patient, with the purpose of boosting the patient’s self-confidence and sense of hope. As a result the patient was able to begin a new life with a positive attitude. This experience is expected to serve as a reference for providing more appropriate nursing care plans for similar patients in clinical settings in the future.