This article was about a patient with end-stage renal disease and lung adenocarcinoma and then she received nursing experience of initial chemical and hemodialysis . The author cared for such a patient from July 31, 2018 to september 30, 2018, Using Gordon’s 11 functional appraisals and both observation and discussion, the following patient’s care issues were identified ,including fluid overload , malnutrition, hopelessness .With these,we can teach the patient skills to control water,and improve the symptoms of asthma caused by fluid overload.Also,we can formulate a diet therapy plan with a dietitian to improve the nutritional imbalance caused by the side effects of chemotherapy. With cross-team care, family and patient support,we can successfully make the patient talk about their difficulties cause by double major diseases in a timely manner,and hopeless economical pressure . I hope to share this care experience and recommend it to the case care seminars of related units.With this, patients of the same nature can face life’s adversity calmly and smoothly.Then,patients will be willing to choose the chemical and hemodialysis treatments, and return to the workplace as soon as possible.