The disease caused by infection of SARS-CoV-2 is called COVID-19. The conditions of the infected patients may be asymptomatic, exhibit mild symptoms, develop severe symptoms, or die of it. Current medication treatment strategies are carried out depending on the severity of the disease. Different medication options are needed for patients with mild symptoms, pneumonia, need of oxygen therapy or noninvasive positive pressure ventilators, or respiratory failure that necessitates intubation. These options include antivirals, monoclonal antibodies, and antiinflammatory drugs. Antiviral drugs and monoclonal antibodies help reduce the virus burden and inhibit virus replication in vivo. Antiinflammatory drugs help reduce the virus-induced inflammation and cytokine storm because of infection. In Taiwan, COVID-19 vaccines including adenovirus vaccines, mRNA vaccines, and protein subunit vaccines have been administered. Even for individuals who have completed the 2-dose primary series, the protection wears off over time. Receiving the third (booster) dose of vaccine can effectively prevent the infection by the Omicron or Delta variants or the development of critical illness.