Greenhouse gas emissions increase global temperature and cause abnormal climate changes, which led to global warming. Due to the rise of environmental awareness, many countries have successfully implemented energy conservation and carbon reduction policies to curb the speed of global warming and reduce the carbon footprint. There are around 60% houses constructed by reinforced concrete buildings in Taiwan. It leads almost 70% of the energy use of the buildings from the consumption of air conditioners in residential and commercial buildings, which shows that the impact of the construction industry on the environment is very serious. Also, to reduce the heat transfer conductivity of reinforced concrete buildings, Taiwan has studied many international building materials for building insulation performance in recent years. In response to the problem of the climate change, the development of new regulations and materials, leads the development of construction to hybrid construction methods in Taiwan. The hybrid structure of wood construction combines the advantage of rigidity, sustainability and enhance efficiency. At the same time, the international community is actively discussing the possibility of future development of wood construction cities Therefore, this study attempts to propose the possibility of developing hybrid wood construction in Kaohsiung, Taiwan. The energy consumption of Reinforced Concrete and Hybrid wood construction are simulated under the premise of meeting the same air-conditioning volume. Also, through the life cycle assessment for the daily use and maintenance session, environmental impacts and carbon emission are calculated. EnergyPlus and SimaPro software are used for simulation It is expected that a new choice for the future development of wooden construction would be proposed.