While the application of medical information is increasingly well developed, it brings out many privacy issues. Based on social cognition theory, this study includes privacy and cognitive factors to develop a research mode and aims to investigate what factors may influence individuals’ intention to disclose medical information. This study conducted a Web survey and 660 usable responses were collected. The analytical results indicate that behavior modeling significantly influences outcome expectations. Behavior modeling, negative emotion of health status, personal influence, privacy policies, legal and government support, trust, and privacy risk significantly influence disclosure self-efficacy. Perceived usefulness, outcome expectation, and disclosure self-efficacy significantly influence individuals’ intention to disclose healthcare information. Finally, implications for academics and practitioners are also provided.