Enterovirus is common for young children under 9 years old and the high risk population for contacting serious enterovirus is young children below 3 years old. This case was a 2 year 5 month old child who had psychological shock due to illness and a strange environment. The child expressed dissatisfaction through the behaviors of frequent crying and resisting treatments during hospitalization. Additionally, the fever, oral pain, and poor appetite problems caused the case’s mother to have anxiety. Therefore, the author was inspired to apply therapeutic play into the nursing care. Gordon 11 health function assessment was used, including observation, interview, photos, and listening methods to comprehensively assess the case during the nursing period from 2017.9.13. to 2017.9.18. Three health problems were identified, including hyper temperature, pain, and ineffective health maintaining ability. Initially the author developed the nursepatient relationship to provide Enterovirus fever nursing interventions. Secondly, the therapeutic play was designed according to the case’s age as the medium of oral mucosa pain care content. Additionally, the fears of oral eating and oral care were alleviated and acceptance of the enterovirus treatment was increased through therapeutic play. Furthermore, the case and caregiver were able to express the inner thoughts appropriately and their disturbance was decreased through consistent care, listening, and empathy provided in the caregiver’s support environment. Finally, the case recovered and was discharged with a discharge planning provided for the caregiver. The author suggests that pediatric medical and nursing staff learn to merge therapeutic play methods into the care process for hospitalized children. In doing so, sick children and caregivers can conduct treatment easily as they intervene to alleviate stress during hospitalization, and approach the goal of promoting the quality of care.