This article describes a nursing experience of a middle-aged male with pemphigus vulgaris suffered from long-term systemic skin and mucosal damage and blister wounds, who treated in an outpatient setting. During this period, Western medication was interrupted and treated with traditional Chinese medicine and remedy, which lead to chronic renal failure requiring hemodialysis. The period of care is from March 15 to April 28, 2018. Eleven functional health assessments of Gordon were used to confirm the individual’s health problems, and confirmed the patient had a high-risk for infections, potentially dangerous falls, and a sense of hopelessness. The care process provides guidance on catheter indwelling and skin wound care, encourages the intake of iron-rich foods to reduce anemia, controls water intake, avoid the occurrence of hypotension during dialysis and improve the safety of the home environment to prevent falls, guide the expression of inner feelings and positive thinking, promote self-worth and confidence. Therefore, the case can face and adjust the disease process and long-term dialysis life changes. We hope that this article can be used as a reference for clinical care of hemodialysis patients with such rare immune diseases.