Hospice care has emerged and evolved over the past 50 years since Dame Cicely Saunders founded the first terminal care facility in London. The idea of maximizing life quality at the end of life has spread throughout the world, triggering the establishment of an increasing number of hospices and monumental changes in regulations. However, hospice care for neurosurgical patients has remained understudied. The patients themselves have to endure tremendous pain, and their families suffer from enormous physical and mental stress, as well as difficulty in decision making. Physicians too are challenged with predicting prognosis. In this article, we reviewed studies regarding indications, benefits and optimal timing of palliative care among victims of traumatic brain injury or severe stroke patients in neurology intensive care units. We discussed the following issues: (1) Disease characteristics of neurosurgical patients and their palliative care needs; (2) The optimal timing for initiating palliative care in these patients; (3) The intervention of the palliative care team in helping patients; (4) The impacts of the promulgated Patient Right to Autonomy Act on neuro-palliative care; and (5) Palliative care skills that should be emphasized during surgery residency.