經電化學陽極處理後之鈦金屬表面所引發凝血性質變化之探討

Titanium Surface Blood Coagulation Changes Induced by Electrochemical Anodization Treatment

本研究是評估鈦金屬表面經電化學陽極處理後凝血性質的變化。牙科用純鈦表面利用電化學陽極處理備製孔洞狀的鈦-氧層，並以凝血測試及血小板貼附來評估其凝血性質。電化學處理結果顯示，經電化學陽極處理後的鈦表面有二氧化鈦的網狀結構生成。凝血測試結果顯示，經電化學陽極處理的鈦試片比未經處理的鈦試片有較短的凝血時間。血小板貼附觀察結果顯示，經電化學處理後的鈦試片有較多的血小板貼附、活化及聚集的現象。牙科用鈦植體材料表面經由電化學陽極處理可產生網狀的二氧化鈦結構，此結構可增進材料的凝血特性。

This study was to evaluate the blood coagulation changes of commercially pure Ti surface after an electrochemical anodization treatment. Anodization treatment was used to produce a porous Ti-O layer on ground Ti surface for dental implant application. The blood coagulation of surface modified Ti specimens was analyzed using kinetic clotting time method and platelet adhesion observation. Results showed that a network TiO2 layer was developed on Ti surface after anodization treatment. The clotting time of surface modified Ti specimens was shorter than that of the untreated Ti specimen. Surface modified Ti specimens had better platelet adhesion, activation and aggregation. According to the present results, we may conclude that the blood coagulation of Ti surface can be improved using an electrochemical anodization treatment via the formation of a network-structured TiO2 surface layer.