| 英文摘要 |
Introduction: Major depressive disorder (MDD) and chronic pain are two highly comorbid conditions and share common biological processes, underlying mechanisms, and pharmacological concepts. We conducted an observational survey to discern the clinical progression of both conditions in the chronic pain patients after short-term pain management.
Methods: This was a longitudinal, questionnaire-based survey involving patients with chronic back pain. Patients received individualized conservative and interventional therapies within 60 days. Based on the Structured Mini-International Neuropsychiatric Interview (MINI) conducted at enrollment, participants were allocated into the MDD and non-MDD groups. Pain intensity, depression, and functional outcomes were assessed at pre- and post-therapies by using the Numeric Rating Scale (NRS), MINI, Oswestry Disability Index, Chalder Fatigue Scale, Neurotoxicity Rating Scale, Hamilton Depression Rating Scale (HAM-D), and Beck Depression Inventory for comparison.
Results: Of the 198 enrolled participants, 95 completed this 60-day study. In the beginning, 29.3% (58/198) were diagnosed with MDD. Across all measures, the MDD group reported significantly worse outcomes than the non-MDD group (P < 0.01) at both baseline and 2 months later. After treatment, HAM-D scores improved significantly in both groups (P < 0.05), while NRS improved significantly only in the non-MDD group (P < 0.01).
Conclusion: MDD is prevalent among chronic pain patients. A combination of conservative and interventional pain management strategies resulted in a significant reduction in depressive symptoms and pain intensity. However, patients with MDD exhibited fewer therapeutic responses compared to those without MDD over the 60-day pain treatment. |
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