| 英文摘要 |
We are currently facing a therapeutic impasse in front of osteoarthritis, but it is the most common reason for rheumatological consultation. However, we have a wide range of medications available, both in terms of administration methods and therapeutic classes. At the forefront of the list are the undefeatable nonsteroidal anti-inflammatory drugs in their oral and/or topical forms and local delayed-release corticosteroid infiltrations. In this case, why is it so difficult to find an osteoarthritis treatment? Our objective was to make a review synthesized into a final algorithm to explain the complexity of pain, to list what provides relief today and tomorrow, and to stick to the essentials while maintaining a healthy mind and body. Recent work suggests that the pain of aging cartilage is“mixed”and composed of a magma of three components: nociceptive, neuropathic, and nociplastic. For this purpose, nerve growth factor inhibitors and promising stem cell therapies have emerged and led the way toward optimal management of osteoarthritis pain. Ultimately, should we not admit that progressive damage to chondral tissue is inevitable in itself and that it constitutes a natural consequence of aging? While waiting for an innovative medication, the key to sustainable treatment will always lie in eating as healthily as possible and maintaining a healthy weight. |
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