2023年南部某醫院嬰兒室新生兒人類副腸孤病毒感染群聚事件

An outbreak of human parechovirus infection in a newborn nursery at a hospital in Southern Taiwan, July–August 2023

2023年8月14日及16日衛生單位接獲醫院通報2名疑似腸病毒併發重症之新生兒，經疫調發現個案皆於某醫院出生並入住該嬰兒室，且均於腦脊髓液檢出人類副腸孤病毒(human parechovirus)，衛生單位遂進行疫情調查及防治輔導。該嬰兒室從7月26日至8月15日收住之21名新生兒中共2名發病，2名個案鼻咽、肛門拭子等檢體，經分子生物學檢驗腸病毒皆為陰性，惟檢出人類副腸孤病毒。因應疫情請該院重新規劃工作動線、定時稽核手部衛生、落實人員健康監測、疫情期間只出不進等防治措施。接觸者45名中有7名出現上呼吸道症狀，針對其中5名有症狀接觸者採檢鼻咽拭子檢驗腸病毒及人類副腸孤病毒，檢驗結果皆為陰性，該嬰兒室監測至9月1日止未再出現新個案。

On August 14 and 16, 2023, health authorities received reports from Hospital A in southern Taiwan of two newborns suspected of having enterovirus infection with severe complications. An epidemiological investigation revealed that both newborns had been born at Hospital B and admitted to the same newborn nursery. Laboratory testing of cerebrospinal fluid revealed the presence of human parechovirus.
In response, health authorities initiated an outbreak investigation and issued infection prevention and control guidance. Among the 21 newborns admitted to the newborn nursery from July 26 to August 15, two developed symptoms. Molecular testing of nasopharyngeal and rectal swabs from these two cases was negative for enterovirus but positive for human parechovirus.
To contain the outbreak, Hospital B was instructed to redesign staff workflows, conduct regular hand hygiene audits, enforce staff health monitoring, and implement a discharge-only policy during the outbreak.
Of the 45 newborn nursery contacts identified, seven had upper respiratory symptoms. Nasopharyngeal swabs collected from five symptomatic contacts were tested for enterovirus and human parechovirus; all results were negative. No additional cases in the nursery were reported through the end of the monitoring period on September 1, 2023.